Why the study?
Does the relief of pressure-overload left ventricular hypertrophy normalize coronary blood flow in a dog model?
Does the relief of pressure-overload left ventricular hypertrophy normalize coronary blood flow in a dog model?
In a canine model, relief of pressure overload leads to regression of LV hypertrophy and normalization of minimum coronary vascular resistance, but endocardial coronary blood flow during pacing-induced stress remains abnormal.
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LVH regression incompletely restores stress-induced endocardial flow in dogs; leaves open whether similar limitations persist after clinical pressure-overload relief.
Ishihara et al. (1992) studied this question.
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