Why the study?
How do left ventricular pressure and inotropic state affect coronary arterial inflow during systole in an anaesthetized dog model?
Population
5 anaesthetized dogs perfused with an extracorporeal circulation system under conditions of maximal…
Comparison
Alteration of ventricular volume and induction… vs Different ventricular volumes and contractility…
Design
Preclinical
Authors
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Suggests pressure-dependent systolic coronary flow limitation in dogs; leaves open translation to human physiology and clinical relevance.
How do left ventricular pressure and inotropic state affect coronary arterial inflow during systole in an anaesthetized dog model?
In a canine model, systolic coronary flow reduction varies with ventricular pressure only when systolic pressure exceeds 100 mmHg, suggesting a shielding effect of the contracting ventricle at lower pressures.
Pagliaro et al. (1998) studied this question.
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