Key result
Abolishing regional contraction with intracoronary lidocaine caused the normalized amplitude of distal phasic coronary velocity to vary significantly with left ventricular pressure (P<0.0001).
Why the study?
Does abolishing local contraction and changing cavity pressure alter phasic myocardial inflow and transmural flow in anesthetized dogs?
Does abolishing local contraction and changing cavity pressure alter phasic myocardial inflow and transmural flow in anesthetized dogs?
p-value: p=<0.0001
Cardiac contraction is the primary determinant of phasic amplitude and transmural distribution of myocardial flow, but left ventricular pressure becomes the dominant factor when regional contraction is abolished.
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Should not change human practice; leaves open translation of contraction-pressure effects on coronary flow to conscious or diseased states.
Doucette et al. (1993) studied this question. Abolishing local contraction (intracoronary lidocaine) and changing cavity pressure vs. Contraction present (normal vs low LVP) was evaluated on Normalized amplitude of distal phasic coronary velocity (NAmp) (p=<0.0001). Abolishing regional contraction with intracoronary lidocaine caused the normalized amplitude of distal phasic coronary velocity to vary significantly with left ventricular pressure (P<0.0001).
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