Why the study?
Does augmenting coronary blood flow and perfusion pressure improve left ventricular contractility in a canine model?
Population
18 dogs on cardiopulmonary bypass providing isovolumetric left ventricular (LV) contractions
Comparison
Augmentation of coronary blood flow and coronary… vs Normal levels of coronary blood flow and pressure
Design
Preclinical
Authors
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Does not support altering clinical perfusion targets; leaves open translation of flow-dependent contractility to human LV dysfunction.
Does augmenting coronary blood flow and perfusion pressure improve left ventricular contractility in a canine model?
Coronary blood flow is an independent determinant of the contractile state of the myocardium, where increased flow augments contractility independent of perfusion pressure.
Abel et al. (1970) studied this question.
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