Key result
Increasing coronary perfusion pressure elevated end-diastolic pressure less in the right ventricle (2.8 mmHg) than the left ventricle (8.9 mmHg; P<0.01), showing less effect on distensibility.
Why the study?
Does an increase in coronary perfusion pressure alter right ventricular distensibility and contractile function differently than in the left ventricle?
Population
8 isolated isovolumically contracting canine hearts
Comparison
Increase in coronary perfusion pressure vs Baseline coronary perfusion pressure and…
Design
Preclinical
Authors
Loading...
May indicate lesser RV distensibility impact from perfusion pressure; extends LV observations in animals but leaves open human translation.
Does an increase in coronary perfusion pressure alter right ventricular distensibility and contractile function differently than in the left ventricle?
Absolute Event Rate: 2.8% vs 8.9%
p-value: p=<0.01
Increasing coronary perfusion pressure enhances contractile function and decreases distensibility in the right ventricle, though to a lesser extent than in the left ventricle.
Fukui et al. (1996) studied Isolated canine hearts (n=8). Increase in coronary perfusion pressure vs. Left ventricle was evaluated on Elevation in end-diastolic pressure (p=<0.01). Increasing coronary perfusion pressure elevated end-diastolic pressure less in the right ventricle (2.8 mmHg) than the left ventricle (8.9 mmHg; P<0.01), showing less effect on distensibility.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: