What question did this study set out to answer?

This study aims to investigate how cardiac contraction influences coronary arterial flow under different vasomotor tones.

May 1, 1994AJP Heart and Circulatory Physiology

Vasomotor tone affects diastolic coronary flow and flow impediment by cardiac contraction similarly

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Population

isolated blood-perfused rat heart with a left ventricular balloon (n = 6)

Comparison

maximal vasodilation with adenosine vs vasomotor tone (control)

Design

Preclinical

Authors

PBPaul A.D. BoumaLeiden University PSP. SipkemaRijnstate Hospital NWNico WesterhofVascular Medicine

Discussion

Member takes

Implication

Should not change clinical practice; extends isolated rat heart data but leaves open in vivo relevance.

Key Points

This study aims to investigate how cardiac contraction influences coronary arterial flow under different vasomotor tones.
Isolated blood-perfused rat heart model (n=6)
Constant perfusion pressure at 105 mmHg
Flow measurement during control and maximal vasodilation with adenosine.
Diastolic flow increased by a factor of 4.06 during vasodilation.
Coronary flow reduction related to developed ventricular pressure (devPLV) and elastance (devELV).
No significant differences in flow effects between control and vasodilation.

Structured PICO

Population

isolated blood-perfused rat heart with a left ventricular balloon (n = 6)

Intervention

maximal vasodilation with adenosine

Comparator

vasomotor tone (control)

Outcome

effect of cardiac contraction on coronary arterial flow (coronary flow reduction, delta CBF)surrogate

Vasodilation increases diastolic coronary flow and flow amplitude similarly without altering the relative contributions of ventricular pressure and contractility in isolated rat hearts.

Cite This Study

Bouma et al. (1994) studied this question.

synapsesocial.com/papers/6a72f996c9955ae7e774901a https://doi.org/10.1152/ajpheart.1994.266.5.h1944

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Vasomotor tone affects diastolic coronary flow and flow impediment by cardiac contraction similarly

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Vasomotor tone affects diastolic coronary flow and flow impediment by cardiac contraction similarly

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider