Key result
Ventricular pacing reduces LAD blood flow velocity ~11% vs right atrial pacing, an effect abolished by adenosine.
Why the study?
The effects of asynchronous mechanical activation by ventricular pacing on coronary arterial blood flow under controlled perfusion pressure and vascular tone were unclear.
Does ventricular pacing reduce coronary arterial blood flow velocity compared to atrial pacing in an open-chest dog model?
Population
14 open-chest dogs
Comparison
Ventricular pacing at RVp, LVp, Apexp vs right atrial pacing
Design
Experimental study with controlled perfusion pressure and pacing protocols
Authors
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Ventricular pacing may compromise regional coronary flow; leaves open whether this affects ischemia risk or outcomes in paced patients.
Does ventricular pacing reduce coronary arterial blood flow velocity compared to atrial pacing in an open-chest dog model?
Effect estimate: 9.7%-12.9% decrease
p-value: p=<0.05
Ventricular pacing reduces coronary blood flow in early activated regions compared to atrial pacing, an effect that appears to be mediated by coronary autoregulation.
Amitzur et al. (1995) studied Normal conditions (animal model) (n=14). Ventricular pacing vs. Atrial pacing was evaluated on Blood flow velocity in the left anterior descending artery (9.7%-12.9% decrease, p=<0.05). Ventricular pacing reduced blood flow velocity in the left anterior descending artery by 9.7%-12.9% compared to right atrial pacing (P<0.05), an effect abolished by adenosine.
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