What does this research mean for the field?

Ventricular pacing decreases overall ventricular performance by attenuating regional myocardial function and blood flow specifically at the pacing area, with local flow decrements closely correlating to decreased myocardial function. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1984Japanese Circulation JournalOpen Access

Effect of pacemaker sites on contractile forces of the local myocardium and blood flow in the major branches of the left coronary artery in anesthetized open-chest dogs.

Q: What is the clinical evidence from this study?

Population: Ventricular pacing (n=12). Intervention: Ectopic electrical pacing at different ventricular sites vs. Different pacing sites (RV, LAD, LCx). Primary outcome: Coronary flow in LAD and LCx and regional myocardial function (p=<0.01).

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Key result

Ventricular pacing decreased ventricular performance with attenuated regional myocardial function and blood flow at the pacing area, with flow decrements closely related to decreased function (p<0.01).

Why the study?

Does the site of ventricular pacing affect regional coronary blood flow and myocardial contractile forces in an open-chest dog model?

Structured PICO

Does the site of ventricular pacing affect regional coronary blood flow and myocardial contractile forces in an open-chest dog model?

Population

12 anesthetized open-chest dogs

Intervention

Ectopic electrical pacing at specific sites (outflow tract of the right ventricle, anterior left ventricular wall, and lateral wall)

Comparator

Comparison between different pacing sites (RV vs LAD vs LCx pacing)

Outcome

Coronary blood flow in the left anterior descending (LAD) and circumflex coronary arteries (LCx) and regional myocardial function (contractile forces)surrogate

Main Result

p-value: p=<0.01

Ventricular pacing decreases ventricular performance by attenuating regional myocardial function and blood flow directly at the pacing site.

Authors

DSDaiji SaitoCity Hospital KTKou TakedaKagawa Prefectural Central Hospital THTazuo HyodoOkayama University

Discussion

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Implication

Site-specific pacing may impair regional flow and function beyond dyssynchrony; leaves open clinical relevance in humans.

Cite This Study

Saito et al. (1984) studied Ventricular pacing (n=12). Ectopic electrical pacing at different ventricular sites vs. Different pacing sites (RV, LAD, LCx) was evaluated on Coronary flow in LAD and LCx and regional myocardial function (p=<0.01). Ventricular pacing decreased ventricular performance with attenuated regional myocardial function and blood flow at the pacing area, with flow decrements closely related to decreased function (p<0.01).

synapsesocial.com/papers/6a15785a5347fbb1739fd533 https://doi.org/10.1253/jcj.48.331

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Effect of pacemaker sites on contractile forces of the local myocardium and blood flow in the major branches of the left coronary artery in anesthetized open-chest dogs.

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Effect of pacemaker sites on contractile forces of the local myocardium and blood flow in the major branches of the left coronary artery in anesthetized open-chest dogs.

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Also Consider