What does this research mean for the field?

Right ventricular apical pacing produces smaller left ventricular end-diastolic and stroke volumes compared to right atrial, left ventricular septal, or left ventricular apical pacing. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This investigation aims to determine how different endocardial pacing sites impact left ventricular performance and deformation in canines.

July 1, 1983Circulation ResearchOpen Access

Endocardial pacing site affects left ventricular end-diastolic volume and performance in the intact anesthetized dog.

Q: What is the clinical evidence from this study?

Population: Left ventricular contraction pattern and performance. Intervention: Pacing from different endocardial sites (right atrium, left ventricular septum, left ventricular apex, right ventricular apex) vs. Normal sinus rhythm and other pacing sites. Primary outcome: Left ventricular three-dimensional contraction pattern, end-diastolic volume, and stroke volume.

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Key result

Right ventricular apical pacing produced the smallest end-diastolic and stroke volume compared with right atrial, left ventricular septal, or left ventricular apical pacing in anesthetized dogs.

Why the study?

Does pacing from different endocardial sites affect left ventricular end-diastolic volume and performance in intact anesthetized dogs?

Population

Intact anesthetized dogs

Comparison

Pacing from different endocardial sites vs Normal sinus rhythm and comparison among pacing…

Design

Preclinical

Authors

MGMaleah GroverUniversity of Michigan SGS A GlantzPublic Health Agency of Canada

Discussion

Member takes

Implication

RV apical pacing may impair LV volumes in anesthetized dogs; leaves open optimal endocardial sites for human hemodynamics.

Key Points

This investigation aims to determine how different endocardial pacing sites impact left ventricular performance and deformation in canines.
Analyzed left ventricular contractions using radiopaque markers and polar decomposition theorem.
Measured end-diastolic volume and stroke volume during pacing from various sites including right atrium and left ventricular apex.
Developed a new statistical procedure to compare different left ventricular cavity deformation patterns.
End-diastolic volume significantly differed among pacing sites, with right ventricular apical pacing resulting in the smallest volume.
End-systolic pressure and volume showed no significant variation across pacing sites.
Beats from right ventricular apical pacing ejected less blood compared to other pacing methods.

Structured PICO

Does pacing from different endocardial sites affect left ventricular end-diastolic volume and performance in intact anesthetized dogs?

Population

Intact anesthetized dogs

Intervention

Pacing from different endocardial sites (right atrium, left ventricular septum, left ventricular apex, right ventricular apex)

Comparator

Normal sinus rhythm and comparison among pacing sites

Outcome

Left ventricular three-dimensional contraction pattern and performance (end-systolic pressure and volume, end-diastolic volume, stroke volume)surrogate

Right ventricular apical pacing results in smaller end-diastolic and stroke volumes compared to right atrial or left ventricular pacing in an anesthetized dog model.

Cite This Study

Grover et al. (1983) studied Left ventricular contraction pattern and performance. Pacing from different endocardial sites (right atrium, left ventricular septum, left ventricular apex, right ventricular apex) vs. Normal sinus rhythm and other pacing sites was evaluated on Left ventricular three-dimensional contraction pattern, end-diastolic volume, and stroke volume. Right ventricular apical pacing produced the smallest end-diastolic and stroke volume compared with right atrial, left ventricular septal, or left ventricular apical pacing in anesthetized dogs.

synapsesocial.com/papers/6a15785a5347fbb1739fd534 https://doi.org/10.1161/01.res.53.1.72

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Endocardial pacing site affects left ventricular end-diastolic volume and performance in the intact anesthetized dog.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Endocardial pacing site affects left ventricular end-diastolic volume and performance in the intact anesthetized dog.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider