August 1, 1996AJP Heart and Circulatory Physiology

Effect of length and contraction on coronary perfusion in isolated perfused papillary muscle of rat heart

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Population

Six isolated, perfused papillary muscles of the rat

Comparison

Changes in muscle length and contractility vs Baseline state

Design

Preclinical

Authors

CACornelis P. AllaartElectrophysiology NWNico WesterhofVascular Medicine

Discussion

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Implication

Challenges pressure-centric models of coronary flow; hypothesis-generating for myocardial elasticity in human coronary physiology.

Structured PICO

Population

Six isolated, perfused papillary muscles of the rat

Intervention

Changes in muscle length (stretch from 80 to 97% of maximum muscle length) and contractility (resumption of pacing or doubling calcium concentration from 1 to 2 mM)

Comparator

Baseline state (e.g., 90% of maximum muscle length, 1 mM calcium)

Outcome

Coronary arterial inflow (diastolic and systolic flow)surrogate

Ventricular pressure is not essential in systolic coronary arterial flow impediment, which instead depends on myocardial elastic properties.

Limitations

Limitations on quantitative comparison due to differences in muscle architecture and differences in force vectors in the papillary muscle and the left ventricle

Cite This Study

Allaart et al. (1996) studied this question.

synapsesocial.com/papers/6a8bdb925dcee0eefbe9459c https://doi.org/10.1152/ajpheart.1996.271.2.h447

View Full Paper

Ask AI

Bookmark

Effect of length and contraction on coronary perfusion in isolated perfused papillary muscle of rat heart

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Effect of length and contraction on coronary perfusion in isolated perfused papillary muscle of rat heart

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider