August 1, 2001AJP Heart and Circulatory Physiology

Decrease in coronary vascular volume in systole augments cardiac contraction

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Population

Tyrode-perfused rat papillary muscle

Comparison

Interfering with coronary vascular volume… vs Low perfusion state / control

Design

Preclinical

Authors

MWMaurice J. J. M. F. WillemsenMaastricht University DDDirk J. DunckerGeneral Cardiology RKRob KramsQueen Mary University of London

Discussion

Member takes

Implication

Should not yet change practice; hypothesis-generating for coronary emptying in myocardial force generation.

Structured PICO

Population

Tyrode-perfused rat papillary muscle

Intervention

Interfering with coronary vascular volume changes by filling with congealed gelatin, perfusing with high viscosity dextran buffer, or placing a silicon tube around the muscle

Comparator

Low perfusion state / control

Outcome

Developed tension (length-tension relationships)surrogate

Emptying of the coronary vasculature during systole facilitates cardiomyocyte thickening and augments force development.

Cite This Study

Willemsen et al. (2001) studied this question.

synapsesocial.com/papers/6a71d8d12163a0a01bc5cf8e https://doi.org/10.1152/ajpheart.2001.281.2.h731

View Full Paper

Ask AI

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Decrease in coronary vascular volume in systole augments cardiac contraction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Decrease in coronary vascular volume in systole augments cardiac contraction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider