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October 1, 2002AJP Heart and Circulatory Physiology

Coronary perfusion and muscle lengthening increase cardiac contraction: different stretch-triggered mechanisms

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Key result

Stretch-activated ion channel blockade with gadolinium completely blunted the increase of developed force and peak calcium by the Gregg effect, but did not affect the Anrep effect in rat myocardium.

Population

Perfused papillary muscles of Wistar rats

Comparison

Muscle length increase from 85% to 95% L at low… vs Baseline conditions before stretch/perfusion…

Design

Preclinical

Authors

RLRegis R. LambertsUniversity of OtagoMRMattie H.P. van RijenUtrecht UniversityPSPieter SipkemaAmsterdam UMC Location Vrije Universiteit Amsterdam

Discussion

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Implication

Distinguishes Gregg from Anrep stretch responses in rat myocardium; leaves open human translation.

Structured PICO

P
Population
Isometrically contracting perfused papillary muscles of Wistar rats.
I
Intervention
Muscle length increase from 85% to 95% L(max) at low and high coronary perfusion before and after inhibition of stretch-activated ion channels (SACs) with gadolinium (10 micromol/l Gd(3+))
C
Comparator
Baseline conditions before stretch/perfusion changes and before SAC inhibition
O
Outcome
Developed force (F(dev)) and intracellular Ca(2+) concentration ([Ca(2+)](i))surrogate

Increased coronary perfusion (transversal stretch) and muscle lengthening (longitudinal stretch) increase myocardial contraction in rats through different stretch-triggered mechanisms, with only the former dependent on stretch-activated ion channels.

Cite This Study

Lamberts et al. (2002) studied this question. Stretch-activated ion channel (SAC) inhibition with gadolinium vs. Before inhibition was evaluated on Developed force (F(dev)) and intracellular Ca(2+) concentration. Stretch-activated ion channel blockade with gadolinium completely blunted the increase of developed force and peak calcium by the Gregg effect, but did not affect the Anrep effect in rat myocardium.

synapsesocial.com/papers/6a75a7ad27eb2deb12e8c61chttps://doi.org/10.1152/ajpheart.00113.2002
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prolonged Diastolic Time Fraction Protects Myocardial Perfusion When Coronary Blood Flow Is Reduced1999 · 84 citations
  2. 2Changes in [Ca2+]i, [Na+]i and Ca2+ current in isolated rat ventricular myocytes following an increase in cell length.1996 · 99 citations
  3. 3Stretch-activated whole cell currents in adult rat cardiac myocytes2000 · 186 citations
  4. 4Ca2+ influx through stretch-activated cation channels activates maxi K+ channels in porcine endocardial endothelium.1994 · 89 citations
  5. 5Measurement of Intracellular Calcium1999 · 768 citations