Key result
Superfusion with reoxygenated coronary venous effluent significantly increased time to half relaxation by 23.0% and decreased positive dF/dtmax by 14.6% in isolated rat papillary muscles.
Effect estimate: RT 1/2 increased by 23.0 +/- 9.0%; positive dF/dtmax decreased by 14.6 +/- 4.7%
Inotropic factors released into the coronary circulation alter papillary muscle contractility independent of coronary perfusion magnitude.
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This isolated rat heart bioassay detects no inotropic factors in coronary effluent; leaves open their role in intact or diseased hearts.
Marieke A. Dijkman (1997) studied this question. Reoxygenated coronary venous effluent vs. Tyrode solution was evaluated on Papillary muscle contractility (peak force, time to half relaxation, and positive dF/dtmax) (RT 1/2 increased by 23.0 +/- 9.0%; positive dF/dtmax decreased by 14.6 +/- 4.7%). Superfusion with reoxygenated coronary venous effluent significantly increased time to half relaxation by 23.0% and decreased positive dF/dtmax by 14.6% in isolated rat papillary muscles.
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