March 1, 1995AJP Heart and Circulatory Physiology

Ca(2+)-free, high-Ca2+ coronary perfusion suppresses contractility and excitation-contraction coupling energy

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Population

8 excised, cross-circulated canine hearts

Design

Preclinical

Follow-up

1-4 hours

Authors

JAJunichi ArakiAlfred I. duPont Hospital for Children MTMiyako TakakiNara Medical University TNT NambaThe University of Osaka

Discussion

Member takes

Implication

This canine model of Ca2+-suppressed contractile failure should not change practice; leaves open mechanistic validation in human HF.

Structured PICO

Population

8 excised, cross-circulated canine hearts

Intervention

Coronary perfusion with Ca(2+)-free Tyrode solution for 10 min followed by high-Ca2+ (16 mM) Tyrode solution for 5 min

Outcome

Mechanoenergetic effects including end-systolic pressure-volume relation (Emax) and relation between oxygen consumption per beat (VO2) and systolic pressure-volume area (PVA)surrogate

A short-term Ca2+-free followed by high-Ca2+ perfusion protocol successfully induces left ventricular contractile failure in canine hearts by suppressing Ca2+ handling energy for excitation-contraction coupling.

Cite This Study

Araki et al. (1995) studied this question.

synapsesocial.com/papers/6a87f1003fe66a1452bbed69 https://doi.org/10.1152/ajpheart.1995.268.3.h1061

Topics

Heart failure HFrEF treatment

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Ca(2+)-free, high-Ca2+ coronary perfusion suppresses contractility and excitation-contraction coupling energy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Ca(2+)-free, high-Ca2+ coronary perfusion suppresses contractility and excitation-contraction coupling energy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider