January 1, 2001The Japanese Journal of PhysiologyOpen Access

Oxygen Wasting for Ca2+ Extrusion Activated by Partial Inhibition of Sarcoplasmic Reticulum Ca2+-ATPase by Cyclopiazonic Acid in Rat Left Ventricles.

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Population

Excised Langendorff-perfused rat whole-heart preparation

Comparison

Cyclopiazonic acid infusion vs Control (baseline) and short-term CPA infusion

Design

Preclinical

Follow-up

12 minutes

Authors

HMHiromi MisawaJapanese Red Cross Society, Japan HKHisaharu KohzukiHimeji Dokkyo University MTMiyako TakakiNara Medical University

Discussion

Member takes

Implication

Raises caution against long-term Ca2+ handling modulation; hypothesis-generating for NCX-mediated energetics in human HF models.

Structured PICO

Population

Excised Langendorff-perfused rat whole-heart preparation

Intervention

Cyclopiazonic acid (CPA; 4 micromol/l) infusion (short-term for 3 to 6 min, long-term for 9 to 12 min)

Comparator

Control (baseline) and short-term CPA infusion

Outcome

Left ventricular myocardial oxygen consumption per beat (Vo2) and systolic pressure-volume area (PVA)surrogate

Inhibition of SR Ca2+-ATPase by cyclopiazonic acid increases the oxygen cost of left ventricular contractility in rat hearts, likely due to energy-wasting Ca2+ extrusion via the Na+/Ca2+ exchanger.

Cite This Study

Misawa et al. (2001) studied this question.

synapsesocial.com/papers/6a91afe605fd6a1e5860eebb https://doi.org/10.2170/jjphysiol.51.99

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Oxygen Wasting for Ca2+ Extrusion Activated by Partial Inhibition of Sarcoplasmic Reticulum Ca2+-ATPase by Cyclopiazonic Acid in Rat Left Ventricles.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Oxygen Wasting for Ca2+ Extrusion Activated by Partial Inhibition of Sarcoplasmic Reticulum Ca2+-ATPase by Cyclopiazonic Acid in Rat Left Ventricles.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider