Increased O2 consumption in excitation–contraction coupling in hypertrophied rat heart slices related to increased Na+–Ca2+ exchange activity
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Why the study?
Does isoproterenol-induced hypertrophy alter O2 consumption in excitation-contraction coupling in rat heart slices?
Population
Male Wistar rats weighing 250–370 g (8–10 weeks), n=74
Comparison
Isoproterenol infusion to induce cardiac… vs Vehicle infusion
Design
Preclinical
Follow-up
3 days
Authors
Discussion
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Member takes
Implication
Should not guide hypertrophy management; leaves open whether ion-handling shifts drive energetics in human disease.
Structured PICO
Does isoproterenol-induced hypertrophy alter O2 consumption in excitation-contraction coupling in rat heart slices?
P
Population
Male Wistar rats weighing 250–370 g (8–10 weeks), n=74
I
Intervention
Isoproterenol infusion (2.4 mg/kg/day subcutaneously for 3 days) to induce cardiac hypertrophy
C
Comparator
Vehicle infusion (0.1% ascorbic acid in saline 2.4 μl/day subcutaneously for 3 days)
O
Outcome
O2 consumption per minute (mVO2) of mechanically unloaded left ventricular slices in the absence and presence of 1-Hz field stimulationsurrogate
In a rat model of isoproterenol-induced cardiac hypertrophy, increased O2 consumption during excitation-contraction coupling is driven by decreased SERCA2 activity and increased Na+-Ca2+ exchange activity.
Cite This Study
Shimizu et al. (2009) studied this question.
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