Key result
Pressure overload in rats enhanced Ca(2+) cycling between the sarcoplasmic reticulum and cytosol early after imposition, even before the development of hypertrophy.
Population
Left ventricular rat myocytes from rats subjected to aortic constriction (pressure overload) or sham operation
Comparison
Pressure overload via aortic constriction… vs Time-matched sham-operated rats
Design
Preclinical
Follow-up
2 and 7 days
Authors
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Caution against clinical extrapolation from rat data; leaves open whether early Ca2+ enhancement is adaptive in human pressure overload.
Enhanced calcium cycling between the sarcoplasmic reticulum and cytosol occurs early after pressure overload, preceding the development of hypertrophy, which may serve as an adaptive and protective mechanism.
Carvalho et al. (2006) studied Pressure overload-induced hypertrophy. Pressure overload (aortic constriction) vs. Sham-operated rats was evaluated on Systolic and diastolic Ca(2+) cycling. Pressure overload in rats enhanced Ca(2+) cycling between the sarcoplasmic reticulum and cytosol early after imposition, even before the development of hypertrophy.
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