Population
Rabbit model of pressure overload-induced cardiac hypertrophy
Comparison
Pulmonary artery banding for 2, 4, 8, and 16 days vs Control rabbits
Design
Preclinical
Follow-up
16 days
Authors
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Supports early SR gene downregulation in rabbit hypertrophy; leaves open translational relevance to human contractile dysfunction.
Pressure overload-induced cardiac hypertrophy in rabbits is associated with significant early and sustained decreases in the expression of key sarcoplasmic reticulum proteins, which may contribute to systolic and diastolic dysfunction.
Matsui et al. (1995) studied this question.
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