January 1, 1999Cardiovascular ResearchOpen Access

Enhanced phosphorylation of phospholamban and downregulation of sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in cardiac sarcoplasmic reticulum from rabbits with heart failure

View Full Paper

Ask AI

Bookmark

Population

Rabbit model of heart failure

Comparison

Heart failure induction via coronary artery… vs Sham-operated animals

Design

Preclinical

Follow-up

8 weeks

Authors

SCSusan CurrieAlbany State University

Discussion

Member takes

Implication

Remains preclinical; leaves open whether phospholamban modulation can restore calcium handling in human heart failure.

Structured PICO

Population

Rabbit model of heart failure (indicated by ventricular contractile dysfunction and lung/liver congestion 8 weeks after coronary artery ligation)

Intervention

Heart failure induction via coronary artery ligation

Comparator

Sham-operated animals

Outcome

Phosphorylation of myocardial phospholamban (PLB), protein levels of PLB and SERCA 2, and rate of Ca2+ uptake into sarcoplasmic reticulum (SR) vesiclessurrogate

In a rabbit model of heart failure, increased phospholamban phosphorylation and decreased SERCA 2 and PLB protein levels lead to a reduced rate of sarcoplasmic reticulum calcium uptake.

Cite This Study

Susan Currie (1999) studied this question.

synapsesocial.com/papers/6a6f3b592163a0a01bc38f3c https://doi.org/10.1016/s0008-6363(98)00241-7

Topics

Heart failure HFrEF treatment

View Full Paper

Ask AI

Bookmark

Enhanced phosphorylation of phospholamban and downregulation of sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in cardiac sarcoplasmic reticulum from rabbits with heart failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Enhanced phosphorylation of phospholamban and downregulation of sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in cardiac sarcoplasmic reticulum from rabbits with heart failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider