Key result
In failing human hearts, mRNA levels for PLB and SERCA2 were reduced by about 30% and 50% respectively, whereas protein levels remained unchanged compared to nonfailing hearts.
Authors
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Does not support protein-level changes as driver of SR dysfunction in HF; leaves open post-transcriptional mechanisms.
Observational
Bettina Linck (2000) conducted an observational in Heart failure. Heart failure (idiopathic dilated cardiomyopathy or ischemic cardiomyopathy) vs. Nonfailing human hearts was evaluated on mRNA and protein levels for PLB and SERCA2. In failing human hearts, mRNA levels for PLB and SERCA2 were reduced by about 30% and 50% respectively, whereas protein levels remained unchanged compared to nonfailing hearts.
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