Key result
Aortic constriction-induced hypertrophied rat cardiomyocytes exhibited a higher amplitude of Ca2+ transients compared to sham-operated rats (0.25 vs 0.17).
Population
Hypertrophied rat left ventricular myocytes induced by aortic constriction (AC) and sham-operated rats
Comparison
Aortic constriction and exposure to… vs Sham-operated rats
Design
Preclinical
Authors
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Adaptive Ca²⁺ handling in compensated hypertrophy may be compensatory; hypothesis-generating and should not guide clinical decisions.
Absolute Event Rate: 0.25% vs 0.17%
Compensated hypertrophied cardiomyocytes exhibit an adaptive increase in calcium transients but reduced myofilament responsiveness and blunted beta-adrenergic response.
Sumida et al. (1998) studied Compensated hypertrophied cardiomyocytes. Aortic constriction vs. Sham operation was evaluated on Amplitude of Ca2+ transients (Ca-Amp). Aortic constriction-induced hypertrophied rat cardiomyocytes exhibited a higher amplitude of Ca2+ transients compared to sham-operated rats (0.25 vs 0.17).
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