July 1, 1999AJP Heart and Circulatory Physiology

Energy expenditure by Ba²⁺contracture in rat ventricular slices derives from cross-bridge cycling

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Population

Mechanically unloaded rat left ventricular (LV) slices

Comparison

Ba2+ contracture, with subsequent addition of… vs Quiescent slices in Ca2+-free Tyrode solution

Design

Preclinical

Authors

HKHisaharu KohzukiHimeji Dokkyo University HMHiromi MisawaJapanese Red Cross Society, Japan SSSusumu SakataNational Institute for Land and Infrastructure Management

Discussion

Member takes

Implication

Rat ventricular slice data should not alter clinical practice; leaves open whether cross-bridge cycling dominates myocardial energetics in humans.

Structured PICO

Population

Mechanically unloaded rat left ventricular (LV) slices

Intervention

Ba2+ contracture (substituting Ca2+ with Ba2+ from 0.3 to 3.0 mmol/l), with subsequent addition of cyclopiazonic acid (CPA, 10 micromol/l) or 2,3-butanedione monoxime (BDM, 5 mmol/l)

Comparator

Quiescent slices in Ca2+-free Tyrode solution (basal metabolism)

Outcome

Myocardial O2 consumption (VO2)surrogate

Energy expenditure during Ba2+ contracture in rat ventricular slices is driven by cross-bridge cycling rather than Ca2+ handling by the sarcoplasmic reticulum Ca2+ pump.

Cite This Study

Kohzuki et al. (1999) studied this question.

synapsesocial.com/papers/6a6fcbf6f44fa9f079dd4a6c https://doi.org/10.1152/ajpheart.1999.277.1.h74

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Implication

Rat ventricular slice data should not alter clinical practice; leaves open whether cross-bridge cycling dominates myocardial energetics in humans.

Energy expenditure by Ba²⁺contracture in rat ventricular slices derives from cross-bridge cycling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Energy expenditure by Ba²⁺contracture in rat ventricular slices derives from cross-bridge cycling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider