April 1, 1991Journal of Applied Physiology

Effect of vasoconstriction on longitudinal distribution of pulmonary vascular pressure and volume

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Population

Dog lung lobe vasculature

Design

Preclinical

Authors

CDC. A. DawsonMarquette University JLJ. H. LinehanNorthwestern University DRD. A. RickabyMedical College of Wisconsin

Discussion

Member takes

Implication

Distinct pulmonary segmental responses may inform targeted vasoactive therapies; hypothesis-generating in animal models and should not yet change practice.

Structured PICO

Population

Dog lung lobe vasculature

Intervention

Vasoconstrictor stimuli including hypoxia, and serotonin, histamine, and norepinephrine infusions

Outcome

Longitudinal (arterial-to-venous) differences in local vascular resistance vs. cumulative vascular volumesurrogate

Different vasoconstrictor stimuli produce distinct longitudinal response patterns in the pulmonary vasculature, affecting specific arterial and venous segments differently.

Cite This Study

Dawson et al. (1991) studied this question.

synapsesocial.com/papers/6a713485f44fa9f079defbe2 https://doi.org/10.1152/jappl.1991.70.4.1607

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Implication

Distinct pulmonary segmental responses may inform targeted vasoactive therapies; hypothesis-generating in animal models and should not yet change practice.

Effect of vasoconstriction on longitudinal distribution of pulmonary vascular pressure and volume

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of vasoconstriction on longitudinal distribution of pulmonary vascular pressure and volume

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider