Key result
Alveolar hypoxia caused vasoconstriction exclusively in pulmonary arteries, serotonin predominantly in arteries, and histamine exclusively in pulmonary veins in isolated dog lungs.
Why the study?
Does alveolar hypoxia, serotonin, or histamine alter pulmonary capillary RBC concentration in isolated dog lungs?
Population
Isolated dog lungs
Comparison
Alveolar hypoxia, serotonin infusion, and… vs Control conditions
Design
Preclinical
Authors
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Findings from isolated lungs warrant clinical caution; leaves open differential vasoreactivity sites in intact lungs.
Does alveolar hypoxia, serotonin, or histamine alter pulmonary capillary RBC concentration in isolated dog lungs?
p-value: p=<0.001
In dog lungs, vasoconstriction occurs exclusively in arteries during alveolar hypoxia, predominantly in arteries during serotonin infusion, and exclusively in veins during histamine infusion.
Glazier et al. (1971) studied Pulmonary vasomotor reactivity (animal model) (n=38). Alveolar hypoxia, serotonin, and histamine infusion vs. Control gas mixture (14.5% O2) and no infusion was evaluated on Capillary red blood cell concentration (RBCs per 10 μm alveolar septum) (p=<0.001). Alveolar hypoxia caused vasoconstriction exclusively in pulmonary arteries, serotonin predominantly in arteries, and histamine exclusively in pulmonary veins in isolated dog lungs.
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