What question did this study set out to answer?

To determine the segmental effects of histamine, 5-hydroxytryptamine, epinephrine, and norepinephrine on pulmonary arterial and venous vascular resistances and lung fluid accumulation.

July 1, 1958American Journal of Physiology-Legacy Content

Effects of Histamine, 5 Hydroxytryptamine and Epinephrine on Pulmonary Hemodynamics With Particular Reference to Arterial and Venous Segment Resistances

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Authors

RGRobert P. GilbertAmes Research Center LHLerner B. HinshawUniversity of Southern California HKHiroshi KuidaUniversity of Utah

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Implication

Experimental study demonstrates differential arterial and venous constriction by vasoactive agents in canine lungs, indicating distinct effects on capillary pressure and fluid retention.

Key Points

To determine the segmental effects of histamine, 5-hydroxytryptamine, epinephrine, and norepinephrine on pulmonary arterial and venous vascular resistances and lung fluid accumulation.
Perfused isolated canine lungs at constant flow while continuously recording pulmonary arterial, left atrial, and wedged pulmonary artery or small vein pressures.
Calculated segmental arterial and venous resistances from measured vascular pressure gradients and tracked continuous alterations in total lung weight following vasoactive drug administration.
Histamine preferentially increased venous vascular resistance over arterial resistance, whereas 5-hydroxytryptamine predominantly increased arterial resistance.
Lung weight decreased during predominant arterial constriction but increased during predominant venous constriction, showing a strong positive correlation with venous resistance change (r = +0.791).
Small pulmonary vein pressures rose following administration of epinephrine, norepinephrine, histamine, and 5-hydroxytryptamine, confirming pulmonary venoconstrictive action.

Cite This Study

Gilbert et al. (1958) studied this question.

synapsesocial.com/papers/6a82b2c17a209f4aae23b757 https://doi.org/10.1152/ajplegacy.1958.194.1.165

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Implication

Experimental study demonstrates differential arterial and venous constriction by vasoactive agents in canine lungs, indicating distinct effects on capillary pressure and fluid retention.

Effects of Histamine, 5 Hydroxytryptamine and Epinephrine on Pulmonary Hemodynamics With Particular Reference to Arterial and Venous Segment Resistances

Discussion

Member takes

Implication

Key Points

Cite This Study

Effects of Histamine, 5 Hydroxytryptamine and Epinephrine on Pulmonary Hemodynamics With Particular Reference to Arterial and Venous Segment Resistances

Discussion

Member takes

Implication

Key Points

Cite This Study

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