Key result
Continuous infusion of vasodilator agents elicited consistent vasodilator responses in dog pulmonary vessels only when they were constricted by serotonin.
Why the study?
Does continuous infusion of vasodilator agents elicit vasodilation in normal and serotonin-constricted pulmonary vessels in dogs?
Population
Dogs (normal and serotonin-constricted pulmonary vessels)
Comparison
Continuous infusion of vasodilator agents vs Normal pulmonary vessels (baseline tone)
Design
Preclinical
Authors
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Baseline tone may determine pulmonary vasodilator efficacy in dogs; leaves open translation to human pulmonary hypertension.
Does continuous infusion of vasodilator agents elicit vasodilation in normal and serotonin-constricted pulmonary vessels in dogs?
The response of the pulmonary vasculature to vasodilator drugs is dependent on the degree of baseline vasoconstrictor tone, with consistent vasodilation occurring in serotonin-constricted vessels.
Rudolph et al. (1959) studied Normal and serotonin-constricted pulmonary vessels. Vasodilator drugs (acetylcholine, histamine, adenosinetriphosphate) vs. Normal pulmonary vessels (baseline) was evaluated on Pulmonary vasomotor responses. Continuous infusion of vasodilator agents elicited consistent vasodilator responses in dog pulmonary vessels only when they were constricted by serotonin.
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