July 1, 1997AJP Lung Cellular and Molecular Physiology

Role of calcium-activated potassium channels and cyclic nucleotides on pulmonary vasoreactivity to serotonin

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Population

Isolated blood-perfused dog lung model

Comparison

Serotonin (10 M) alone or with… vs Baseline or control conditions

Design

Preclinical

Authors

SBScott A. BarmanAugusta University

Discussion

Member takes

Implication

May guide mechanistic studies of pulmonary tone in animals; leaves open human translation.

Structured PICO

Population

Isolated blood-perfused dog lung model

Intervention

Serotonin (10(-5) M) alone or with Tetraethylammonium ions (TEA+; 1 mM), 3-isobutyl-1-methylxanthine (10(-5) M), dibutyryl-cAMP (10(-5) M), isoproterenol (10(-5) M), or 8-bromo-cGMP (10(-5) M)

Comparator

Baseline or control conditions

Outcome

Pulmonary vascular resistances and compliancessurrogate

cAMP-induced pulmonary vasodilation is mediated primarily by Ca(2+)-activated K+ channels, which attenuate the pressor response to serotonin in canine pulmonary blood vessels.

Cite This Study

Scott A. Barman (1997) studied this question.

synapsesocial.com/papers/6a8d1cb60bd5a3045f314c6a https://doi.org/10.1152/ajplung.1997.273.1.l142

View Full Paper

Ask AI

Bookmark

Role of calcium-activated potassium channels and cyclic nucleotides on pulmonary vasoreactivity to serotonin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Role of calcium-activated potassium channels and cyclic nucleotides on pulmonary vasoreactivity to serotonin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider