September 1, 1999AJP Lung Cellular and Molecular Physiology

Potassium channels modulate canine pulmonary vasoreactivity to protein kinase C activation

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Population

Isolated blood-perfused dog lung

Design

Preclinical

Authors

SBScott A. BarmanAugusta University

Discussion

Member takes

Implication

K+ channel openers may blunt PKC-driven pulmonary vasoconstriction in canines; leaves open translation to human pulmonary vascular disease.

Structured PICO

Population

Isolated blood-perfused dog lung

Intervention

Protein kinase C (PKC) activators phorbol 12-myristate 13-acetate (PMA; 10(-7) M) and thymeleatoxin (THX; 10(-7) M) alone or in combination with K+ channel blockers (tetraethylammonium ions, glibenclamide, 4-aminopyridine), K+ channel openers (cromakalim), or KCl

Outcome

Pulmonary vascular resistances and compliancessurrogate

Potassium channels modulate the canine pulmonary vasoconstrictor response to protein kinase C activation.

Cite This Study

Scott A. Barman (1999) studied this question.

synapsesocial.com/papers/6a83e8024d653d38678de685 https://doi.org/10.1152/ajplung.1999.277.3.l558

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Bookmark

Implication

K+ channel openers may blunt PKC-driven pulmonary vasoconstriction in canines; leaves open translation to human pulmonary vascular disease.

Potassium channels modulate canine pulmonary vasoreactivity to protein kinase C activation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Potassium channels modulate canine pulmonary vasoreactivity to protein kinase C activation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider