What does this research mean for the field?

Calcium- and/or voltage-activated potassium channels, rather than ATP-sensitive potassium channels, play an important role in maintaining low pulmonary vascular tone. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 1, 1991American Review of Respiratory Disease

Effects of K+ Channel Blockers on Vascular Tone in the Perfused Rat Lung

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Structured PICO

Population

Meclofenamate-treated salt solution-perfused rat lungs

Intervention

K+ channel blockers (tetraethylammonium chloride 1 to 20 mM, 4-aminopyridine 1 to 10 mM) and ATP-sensitive K+ channel inhibitor (glibenclamide 1 to 20 microM)

Outcome

Pulmonary vascular tone (vasoconstriction/pressor effects)surrogate

Ca(++)- and/or voltage-activated K+ channels, but not ATP-sensitive K+ channels, may be important in maintaining low pulmonary vascular tone.

Discussion

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Implication

Highlights Ca++- and voltage-activated K+ channels in pulmonary tone; hypothesis-generating, not ready for clinical translation.

Cite This Study

Hasunuma et al. (1991) studied this question.

synapsesocial.com/papers/6a197ee6c05413006f586b48 https://doi.org/10.1164/ajrccm/144.4.884

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Effects of K+ Channel Blockers on Vascular Tone in the Perfused Rat Lung

Structured PICO

Discussion

Implication

Cite This Study

Effects of K+ Channel Blockers on Vascular Tone in the Perfused Rat Lung

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider