Why the study?
Does serotonin infusion alter proximal coronary artery dimensions in awake dogs?
Population
Awake dogs chronically instrumented with miniature piezoelectric dimension crystals on the proximal…
Comparison
Serotonin infused as a bolus in the left atrium… vs Baseline/control state before interventions or…
Design
Preclinical
Follow-up
Acute (minutes to 1-2 days)
Authors
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Endothelial modulation of serotonin's coronary effects in dogs warrants caution extrapolating to humans; extends mechanistic insights but leaves clinical translation open.
Does serotonin infusion alter proximal coronary artery dimensions in awake dogs?
In awake dogs, serotonin induces a biphasic coronary vasomotor response with initial endothelium-dependent vasodilation followed by direct smooth muscle vasoconstriction.
Chu et al. (1987) studied this question.
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