Key result
During hypoperfusion, serotonin decreased subendocardial flow from 0.51 to 0.35 ml/min/g (p<0.05), suggesting it selectively increases resistance to subendocardial blood flow.
Why the study?
Does serotonin alter myocardial blood flow distribution during exercise in the presence of a coronary artery stenosis in dogs?
Does serotonin alter myocardial blood flow distribution during exercise in the presence of a coronary artery stenosis in dogs?
p-value: p=<0.05
Serotonin selectively aggravates subendocardial ischemia distal to a coronary stenosis during exercise by constricting intramural penetrating arteries.
May warrant caution with serotonergic agents during ischemia; leaves open relevance to human coronary syndromes.
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Bache et al. (1992) studied Myocardial hypoperfusion during exercise (n=7). Serotonin vs. Control exercise (before serotonin infusion) was evaluated on Subendocardial myocardial blood flow (p=<0.05). During hypoperfusion, serotonin decreased subendocardial flow from 0.51 to 0.35 ml/min/g (p<0.05), suggesting it selectively increases resistance to subendocardial blood flow.
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