October 1, 1980Circulation ResearchOpen Access

Reflex cardiovascular and respiratory effects of serotonin in conscious and anesthetized dogs.

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Structured PICO

Population

Conscious dogs (n=8), anesthetized closed-chest dogs (n=13), and anesthetized open-chest dogs (n=9)

Intervention

Intra-left atrial or intra-left ventricular injection of serotonin (50-200 microgram) as a bolus

Comparator

Baseline/control state

Outcome

Cardiovascular and respiratory effects (blood pressure, heart rate, respiratory depth and rate)surrogate

The cardiovascular reflex response to serotonin is dramatically altered by anesthesia and surgical preparation in dogs.

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Anesthesia and surgery alter serotonin cardiovascular reflexes in dogs; leaves open translation to conscious or human physiology.

Zucker et al. (1980) studied this question.

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