What question did this study set out to answer?

This study investigates how bradykinin stimulation affects heart function and blood pressure in conscious dogs.

December 1, 1981Clinical Science

A Sympathetic Hypertensive Reflex from the Heart of Conscious Dogs

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Why the study?

Does chemical stimulation of cardiac sensory innervation by bradykinin induce a sympathetic hypertensive reflex in conscious dogs?

Population

Conscious dogs with implanted catheters (n=5)

Design

Preclinical

Authors

MPM. PaganiCentro Universitário Cesumar PPPaolo PizzinelliUniversity of Milan RFRaffaello FurlanGeneral Cardiology

Discussion

Member takes

Implication

Challenges anesthetized depressor concepts; leaves open conscious-state translation and human relevance.

Key Points

This study investigates how bradykinin stimulation affects heart function and blood pressure in conscious dogs.
Chemical stimulation with bradykinin (100 ng/kg) administered into the left coronary artery of conscious dogs
Measurement of mean arterial pressure, heart rate, left ventricular pressure, and coronary blood flow
Conducted on a sample of 5 conscious dogs with implanted catheters.
Bradykinin injection caused significant increases in mean arterial pressure and heart rate (P<0.01)
Notable increases in left ventricular pressure and dP/dt max observed
Pressor sympathetic reflexes were identified without pain reactions.

Structured PICO

Does chemical stimulation of cardiac sensory innervation by bradykinin induce a sympathetic hypertensive reflex in conscious dogs?

Population

Conscious dogs with implanted catheters (n=5)

Intervention

Bradykinin (100 ng/kg) injected into a cannulated branch of the left coronary artery

Outcome

Changes in mean arterial pressure, heart rate, left ventricular pressure, left ventricular dP/dt max, and coronary blood flowsurrogate

Chemical stimulation of the intact sensory supply of the heart by bradykinin in conscious dogs elicits a pressor sympathetic reflex, challenging the previous concept derived from anesthetized animals that it always elicits a depressor reflex.

Cite This Study

Pagani et al. (1981) studied this question.

synapsesocial.com/papers/6a2145995c0c8498e257d552 https://doi.org/10.1042/cs061181s

Topics

Hypertension management

View Full Paper

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A Sympathetic Hypertensive Reflex from the Heart of Conscious Dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

A Sympathetic Hypertensive Reflex from the Heart of Conscious Dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider