Why the study?
Does epicardial application of bradykinin and capsaicin elicit enhanced cardiac sympathetic afferent reflexes in dogs with congestive heart failure compared to normal dogs?
Does epicardial application of bradykinin and capsaicin elicit enhanced cardiac sympathetic afferent reflexes in dogs with congestive heart failure compared to normal dogs?
The cardiac sympathetic afferent reflex is sensitized in the heart failure state, potentially contributing to the sustained higher sympathetic tone observed in chronic heart failure.
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Hypothesis-generating for sensitized cardiac sympathetic afferents in experimental HF; leaves open translation to human sympathetic overdrive and therapy.
Wang et al. (1996) studied this question.
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