February 1, 2001AJP Heart and Circulatory Physiology
Volume expansion potentiates cardiac sympathetic afferent reflex in dogs
Population
10 normal dogs with sino-aortic denervation and bilateral cervical vagotomy
Comparison
Blood volume expansion via infusion of isosmotic… vs Pre-volume expansion baseline
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for volume expansion potentiating sympathetic reflexes in HF; should not change practice pending human studies.
Structured PICO
P
Population
10 normal dogs with sino-aortic denervation and bilateral cervical vagotomy
I
Intervention
Blood volume expansion via infusion of isosmotic dextran into a femoral vein (40 ml/kg at 50 ml/min), with cardiac sympathetic afferent reflex (CSAR) elicited by epicardial application of bradykinin (5 and 50 microg) and capsaicin (10 and 100 microg)
C
Comparator
Pre-volume expansion baseline
O
Outcome
Renal sympathetic nerve activity (RSNA) response to epicardial bradykinin and capsaicinsurrogate
Acute volume expansion potentiates the cardiac sympathetic afferent reflex, suggesting that cardiac dilation in congestive heart failure may mediate enhanced sympathetic activity.
Cite This Study
Wang et al. (2001) studied this question.