Key result
Acute volume expansion increases peak baroreceptor discharge ~27% in dogs with open carotid sinuses.
Why the study?
Does acute volume expansion enhance baroreceptor discharge in normal dogs?
Population
Normal dogs
Comparison
Acute volume expansion with isotonic, isoncotic… vs Control state and a group with the carotid sinus…
Design
Preclinical
Authors
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May implicate humoral or flow factors in baroreceptor sensitization; leaves open translation to human volume regulation or baroreflex therapies.
Does acute volume expansion enhance baroreceptor discharge in normal dogs?
Absolute Event Rate: 49.9% vs 39.2%
p-value: p=<0.05
Acute volume expansion augments baroreceptor discharge in dogs, a phenomenon that may be mediated by circulating substances or increased flow through the carotid sinus.
Wang et al. (1992) studied Normal dogs. Acute volume expansion with isotonic, isoncotic dextran in normal saline vs. Control state was evaluated on Peak baroreceptor discharge (p=<0.05). Acute volume expansion augmented baroreceptor peak discharge in dogs with the carotid sinus open to the circulation (49.9 vs. 39.2 spikes/s, P<0.05).
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