Key result
Intracoronary bradykinin at 100 ng/kg produced a reflex pressor response, increasing mean arterial pressure by 28% and heart rate by 30% (P<0.01), mediated by sympathetic afferent pathways.
Why the study?
Does intracoronary bradykinin produce a pressor sympathetic reflex in conscious dogs?
Population
20 conscious instrumented dogs
Comparison
Intracoronary injections of bradykinin vs Baseline and post-pharmacological…
Design
Preclinical
Authors
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Confirms sympathetic cardiac afferent reflexes in conscious dogs; leaves open translation to human reflex control.
Does intracoronary bradykinin produce a pressor sympathetic reflex in conscious dogs?
p-value: p=<0.01
Intracoronary bradykinin elicits a sympathetic pressor reflex in conscious dogs without causing pain, with afferent pathways in the sympathetic nerves.
Pagani et al. (1985) studied this question. Intracoronary bradykinin was evaluated on Hemodynamic effects including mean arterial pressure, left ventricular pressure, and heart rate (p=<0.01). Intracoronary bradykinin at 100 ng/kg produced a reflex pressor response, increasing mean arterial pressure by 28% and heart rate by 30% (P<0.01), mediated by sympathetic afferent pathways.
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