Population
Rats slightly anesthetized with hexobarbital, implanted with femoral catheters for blood pressure and heart…
Comparison
Graded doses of bradykinin injected… vs Intravenous administration, or intrapericardial…
Design
Preclinical
Authors
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May drive sympathetic activation in cardiac ischemia; leaves open human translation and therapeutic targeting.
Cardiac bradykinin elicits a sympathoexcitatory reflex via epicardial B2 receptors and sympathetic cardiac afferent fibers in rats, which may contribute to increased sympathetic activity during cardiac ischemia.
Veelken et al. (1996) studied this question.
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