Why the study?
Does inhibition of the paraventricular nucleus reduce the cardiogenic sympathetic reflex in rats?
Population
Anesthetized rats (n=31)
Comparison
Bilateral microinjection of muscimol or… vs Vehicle injection into the PVN followed by…
Design
Preclinical
Authors
Loading...
Supports tonic PVN role in cardiogenic sympathoexcitation in rats; hypothesis-generating and should not yet change practice.
Does inhibition of the paraventricular nucleus reduce the cardiogenic sympathetic reflex in rats?
Tonic paraventricular nucleus activity is important for the full manifestation of the cardiogenic sympathoexcitatory response in rats, though ionotropic glutamate receptors are not directly involved.
Zahner et al. (2004) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: