Paraventricular nucleus is involved in the central pathway of cardiac sympathetic afferent reflex in rats
Key result
Inhibition or lesion of the paraventricular nucleus abolished the cardiac sympathetic afferent reflex, while excitation of its neurons enhanced the reflex in rats.
Why the study?
Does modulation of the paraventricular nucleus affect the cardiac sympathetic afferent reflex in rats?
Population
Anaesthetized Sprague-Dawley rats with sinoaortic denervation and cervical vagotomy
Comparison
Bilateral microinjection of lignocaine or… vs Baseline state
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Identifies paraventricular nucleus as central mediator of cardiac sympathetic afferent reflex in rats; hypothesis-generating for human autonomic targets.
Structured PICO
Does modulation of the paraventricular nucleus affect the cardiac sympathetic afferent reflex in rats?
P
Population
Anaesthetized Sprague-Dawley rats with sinoaortic denervation and cervical vagotomy.
I
Intervention
Bilateral microinjection of lignocaine or l-glutamate, bilateral electrolytic lesions, or bilateral selective lesions with kainic acid into the paraventricular nucleus (PVN)
C
Comparator
Baseline state
O
Outcome
Cardiac sympathetic afferent reflex (CSAR) evaluated by the response of renal sympathetic nerve activity (RSNA) to epicardial application of bradykinin or capsaicinsurrogate
The paraventricular nucleus is a crucial component of the central neurocircuitry mediating the cardiac sympathetic afferent reflex.
Cite This Study
Zhong et al. (2008) studied this question. Modulation of the paraventricular nucleus (inhibition, excitation, or lesion) vs. Baseline was evaluated on Cardiac sympathetic afferent reflex (CSAR) response. Inhibition or lesion of the paraventricular nucleus abolished the cardiac sympathetic afferent reflex, while excitation of its neurons enhanced the reflex in rats.