Key result
In a rat model of renovascular hypertension, superoxide anions in the paraventricular nucleus mediate the enhanced cardiac sympathetic afferent reflex and sympathetic activity.
Population
Renovascular hypertensive rats (two-kidney, one-clip [2K1C] model) and sham-operated rats
Comparison
Paraventricular nucleus microinjection of… vs Sham-operated rats; baseline states
Design
Preclinical
Authors
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Implicates paraventricular superoxide in sympathetic overdrive in renovascular hypertension rats; extends mechanistic insights but leaves open human translation.
Increased superoxide anions in the paraventricular nucleus contribute to the enhanced cardiac sympathetic afferent reflex and sympathetic activity in renovascular hypertension.
Han et al. (2010) studied Renovascular hypertension. PVN microinjection of tempol, apocynin, DETC, or ANG II vs. Sham-operated rats was evaluated on Cardiac sympathetic afferent reflex (CSAR), renal sympathetic nerve activity (RSNA), and mean arterial pressure (MAP). In a rat model of renovascular hypertension, superoxide anions in the paraventricular nucleus mediate the enhanced cardiac sympathetic afferent reflex and sympathetic activity.
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