Why the study?
Does the cardiac sympathetic afferent reflex contribute to sympathetic overactivity in renovascular hypertensive rats, and what is the role of central AT1 receptors?
Population
Two-kidney one-clip renovascular hypertensive rats and sham-operated rats
Comparison
Epicardial application of capsaicin… vs Sham-operated rats and baseline measurements
Design
Preclinical
Authors
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Should not change clinical practice; leaves open central AT1 receptor targeting in human renovascular hypertension.
Does the cardiac sympathetic afferent reflex contribute to sympathetic overactivity in renovascular hypertensive rats, and what is the role of central AT1 receptors?
The cardiac sympathetic afferent reflex is enhanced in renovascular hypertensive rats and contributes to sympathetic activation and hypertension via central AT1 receptors.
Zhu et al. (2009) studied this question.
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