Why the study?
Does ANG II in the paraventricular nucleus potentiate the cardiac sympathetic afferent reflex in rats with heart failure?
Population
Rats with coronary ligation-induced chronic heart failure (CHF) and sham-operated rats
Comparison
Microinjection of AT1-receptor antagonist… vs Sham rats and/or baseline responses
Design
Preclinical
Authors
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Central ANG II augments sympathetic reflexes via PVN AT1 receptors in experimental CHF; leaves open translation to human sympathoexcitation therapies.
Does ANG II in the paraventricular nucleus potentiate the cardiac sympathetic afferent reflex in rats with heart failure?
In a rat model of heart failure, ANG II in the paraventricular nucleus augments the cardiac sympathetic afferent reflex via AT1 receptors, contributing to sympathoexcitation.
Zhu et al. (2004) studied this question.
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