Key result
The cardiac sympathetic afferent reflex and its responses to angiotensin II in the paraventricular nucleus are enhanced in intact chronic heart failure rats, and are inhibited by baroreceptor and vagal afferent activities.
Population
96 male Sprague-Dawley rats with coronary ligation-induced chronic heart failure or sham operation.
Comparison
Baroreceptor denervation + vagotomy, vagotomy… vs Sham-operated rats, intact rats, or saline…
Design
Preclinical, The rats were randomly subjected to the ligation of the left…
Follow-up
Acute experiment carried out 7 weeks after coronary…
Authors
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Does not alter HF management; leaves open whether reflex modulation by baroreceptor/vagal inputs or angiotensin II offers human therapeutic targets.
p-value: p=<0.05
This preclinical study demonstrates that the cardiac sympathetic afferent reflex is enhanced in intact heart failure rats, and that baroreceptor and vagal afferent inputs normally inhibit this reflex and its augmentation by angiotensin II.
Gan et al. (2011) studied Chronic heart failure. Baroreceptor denervation and vagotomy vs. Intact (INT) or Sham was evaluated on Renal sympathetic nerve activity (RSNA) and mean arterial pressure (MAP) responses to epicardial application of capsaicin (p=<0.05). The cardiac sympathetic afferent reflex and its responses to angiotensin II in the paraventricular nucleus are enhanced in intact chronic heart failure rats, and are inhibited by baroreceptor and vagal afferent activities.
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