Why the study?
Does intracoronary ketanserin inhibit serotonin-induced coronary vasoconstriction in patients with stable or variant angina?
Does intracoronary ketanserin inhibit serotonin-induced coronary vasoconstriction in patients with stable or variant angina?
Functionally important S1-like receptors mediate vasoconstriction in the epicardial vessels of patients with stable or variant angina, which is not inhibited by the S2 receptor antagonist ketanserin.
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Ketanserin fails to prevent occlusion in variant angina; leaves open whether S1-like receptor blockade is required.
McFadden et al. (1992) studied this question.
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