Why the study?
Does intracoronary ketanserin improve coronary vasoconstriction in epicardial coronary arteries immediately after PTCA in patients with stable angina?
Population
Patients with chronic stable angina subjected to percutaneous coronary angioplasty
Comparison
Intracoronary infusion of 1 mg ketanserin… vs Control vessels not subjected to PTCA and…
Design
Case_series
Follow-up
Immediately after PTCA
Authors
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Suggests 5-HT2-mediated post-PTCA vasoconstriction; single case leaves open need for controlled trials before any clinical role.
Does intracoronary ketanserin improve coronary vasoconstriction in epicardial coronary arteries immediately after PTCA in patients with stable angina?
Intracoronary ketanserin reverses post-PTCA distal vasoconstriction, demonstrating that this acute vasomotor response is mediated at least in part by 5-HT2 receptors.
Tousoulis et al. (1994) studied this question.
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