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February 24, 1994New England Journal of Medicine

Local Effect of Serotonin Released during Coronary Angioplasty

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Why the study?

Does ketanserin prevent coronary vasoconstriction caused by serotonin release during coronary angioplasty?

Population

15 patients scheduled to undergo angioplasty of the left anterior descending or circumflex coronary artery.

Comparison

Ketanserin administered before angioplasty. vs No ketanserin (control group).

Design

Cohort

Follow-up

15 minutes after the last dilation

Authors

PGPaolo GolinoFPFederico PiscioneCBClaude R. Benedict

Discussion

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Overview

May blunt distal vasoconstriction during angioplasty; hypothesis-generating observational data requiring randomized confirmation before practice change.

Structured PICO

Does ketanserin prevent coronary vasoconstriction caused by serotonin release during coronary angioplasty?

P
Population
15 patients scheduled to undergo angioplasty of the left anterior descending or circumflex coronary artery (8 in the control group, 7 in the ketanserin group).
I
Intervention
Ketanserin (a serotonin2-receptor antagonist) administered before angioplasty.
C
Comparator
No ketanserin (control group).
O
Outcome
Serotonin levels in plasma from the coronary sinus and ascending aorta, and cross-sectional area of the coronary artery distal to the site of dilation measured angiographically 5 and 15 minutes after the last dilation.surrogate

Serotonin is released into the coronary circulation during angioplasty and contributes to distal vasoconstriction, which can be effectively attenuated by the serotonin2-receptor antagonist ketanserin.

Cite This Study

Golino et al. (1994) studied this question.

synapsesocial.com/papers/6a94605fa0ae96a16adf343bhttps://doi.org/10.1056/nejm199402243300802
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