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September 22, 1998CirculationOpen Access

Percutaneous Transluminal Coronary Angioplasty Reverses Vasoconstriction of Stenotic Coronary Arteries in Hypertensive Patients

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Why the study?

Does PTCA reverse exercise-induced vasoconstriction of stenotic coronary arteries in patients with coronary artery disease and hypertension?

Population

39 patients with coronary artery disease (21 normotensive and 18 hypertensive)

Comparison

Percutaneous Transluminal Coronary Angioplasty vs Pre-PTCA baseline and normotensive vs…

Design

Cohort

Follow-up

9+/-3 months

Authors

JFJürgen FrielingsdorfPKPhilipp A. KaufmannTSThomas Suter

Discussion

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Member takes

Overview

Supports PTCA for vasomotor effects in hypertensive CAD; leaves open outcome impact in prospective trials.

Structured PICO

Does PTCA reverse exercise-induced vasoconstriction of stenotic coronary arteries in patients with coronary artery disease and hypertension?

P
Population
39 patients with coronary artery disease (21 normotensive and 18 hypertensive)
I
Intervention
Percutaneous Transluminal Coronary Angioplasty (PTCA)
C
Comparator
Pre-PTCA baseline (within-patient comparison) and normotensive vs hypertensive groups
O
Outcome
Coronary vasomotion (luminal area changes) of normal and stenotic vessel segments during supine bicycle exercise, determined by biplane quantitative coronary arteriographysurrogate

PTCA reverses paradoxical exercise-induced vasoconstriction in stenotic coronary arteries in both normotensive and hypertensive patients.

Cite This Study

Frielingsdorf et al. (1998) studied this question.

synapsesocial.com/papers/6a1c5e7abc71fb1015a97420https://doi.org/10.1161/01.cir.98.12.1192
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