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December 2, 1989European Heart JournalOpen Access

Coronary stenosis vasomotion during dynamic exercise before and after PTCA

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Why the study?

Does PTCA improve exercise-induced coronary vasomotion in stenotic coronary arteries in patients with coronary disease?

Population

8 patients with coronary disease, mean age 50 +/- 8 years.

Comparison

Percutaneous transluminal coronary angioplasty vs Pre-PTCA baseline (within-patient comparison)

Design

Cohort

Follow-up

3.3 +/- 1.9 months

Authors

TSThomas SuterOHOtto M. HessABAlessandro Santo Bortone

Discussion

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Overview

PTCA attenuates exercise-induced vasoconstriction in stenotic segments; hypothesis-generating for vasomotor benefit and requires confirmation in randomized trials.

Structured PICO

Does PTCA improve exercise-induced coronary vasomotion in stenotic coronary arteries in patients with coronary disease?

P
Population
8 patients with coronary disease, mean age 50 +/- 8 years.
I
Intervention
Percutaneous transluminal coronary angioplasty (PTCA)
C
Comparator
Pre-PTCA baseline (within-patient comparison)
O
Outcome
Luminal area of normal and stenotic coronary arteries at rest, during supine bicycle exercise, and 5 min after 1.6 mg sublingual nitroglycerinsurrogate

PTCA significantly attenuates exercise-induced vasoconstriction in previously stenotic coronary arteries.

Cite This Study

Suter et al. (1989) studied this question.

synapsesocial.com/papers/6a0faef94fb650da4ffe6443https://doi.org/10.1093/eurheartj/10.suppl_g.58
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Vasoconstriction of stenotic coronary arteries during dynamic exercise in patients with classic angina pectoris: reversibility by nitroglycerin.1986 · 373 citations
  2. 2Reflex constriction of significant coronary stenosis as a mechanism contributing to ischemic left ventricular dysfunction during isometric exercise.1984 · 241 citations
  3. 3On the Fluid Mechanics of Human Coronary Artery Stenosis1975 · 159 citations
  4. 4Sympathetic Control of Coronary Circulation1967 · 209 citations
  5. 5Quantitative coronary arteriography: estimation of dimensions, hemodynamic resistance, and atheroma mass of coronary artery lesions using the arteriogram and digital computation.1977 · 635 citations