September 1, 1994CirculationOpen Access

Variable participation of 5-HT1-like receptors and 5-HT2 receptors in serotonin-induced contraction of human isolated coronary arteries. 5-HT1-like receptors resemble cloned 5-HT1D beta receptors.

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Population

Epicardial coronary arteries dissected from the hearts of 29 patients undergoing heart transplant operation.

Design

Preclinical

Authors

AKAlberto J. KaumannElectrophysiology MFMiriam FrenkenDüsseldorf University Hospital HPHerbert PosivalHeidelberg University

Discussion

Member takes

Implication

5-HT1-like predominance in coronary contraction warrants caution extrapolating to humans; leaves open selective antagonism for vasospasm.

Structured PICO

Population

Epicardial coronary arteries dissected from the hearts of 29 patients (including 1 healthy donor) undergoing heart transplant operation.

Intervention

Serotonin (5-HT) with or without ketanserin (0.1 to 1.0 mumol/L) and methiothepin (0.1 mumol/L), and sumatriptan

Outcome

Fractional contributions of 5-HT1-like and 5-HT2 receptors to the maximum effect of 5-HT (f1 and f2)surrogate

In human isolated coronary arteries, serotonin-induced contractions are predominantly mediated by 5-HT1-like receptors that resemble cloned 5-HT1D beta receptors.

Cite This Study

Kaumann et al. (1994) studied this question.

synapsesocial.com/papers/6a7dbfc1699b737ada99a06c https://doi.org/10.1161/01.cir.90.3.1141

Topics

Women and heart disease

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Variable participation of 5-HT1-like receptors and 5-HT2 receptors in serotonin-induced contraction of human isolated coronary arteries. 5-HT1-like receptors resemble cloned 5-HT1D beta receptors.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Variable participation of 5-HT1-like receptors and 5-HT2 receptors in serotonin-induced contraction of human isolated coronary arteries. 5-HT1-like receptors resemble cloned 5-HT1D beta receptors.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

Also Consider